Born Ernest Kador, Jr., in New Orleans, Louisiana, K-Doe is perhaps best known for colorful personality and his 1961 hit song "Mother-In-Law," which went to No. 1 on the Billboard Hot 100 in the United States. K-Doe predicted that the only currently familiar tunes which will still be known in 1,000 years are "The Star Spangled Banner" and his "Mother In Law". His next biggest hit was "A Certain Girl".
In the 1980s he did radio shows on New Orleans community stations WWOZ and WTUL. The shows were known for his explosively energetic announcements and frequent self promotion (occasionally causing problems for the non-commercial station). K-Doe's catch phrases included "Burn, K-Doe, Burn!" "I'm a Charity Hospital Baby!" and (addressed to himself) "You just good, that's all!". For a time he billed himself as "Mister Naugahyde" until he was ordered to desist by the owners of the Naugahyde trademark. K-Doe then explained that it was a misunderstanding; he was actually referring to himself as "Mister M-Nauga-Ma-Hyde", a word he invented himself.
Ernie K-Doe died in 2001 and, after a traditional jazz funeral, was interred in the 200-year-old Duval tomb in Saint Louis Cemetery #2, in his native New Orleans. He had burial space in his father's family cemetery in Irvinville, LA, but his widow, Antoinette, as well as his fans and friends in New Orleans, wanted his remains in the city, so the Duval family offered him some of their burial space. He is buried in the same tomb with his second mother-in-law, with whom he was very close, and his best friend, legendary Earl King.
His widow, Antoinette K-Doe, continued to operate his music club/bar, "Ernie K-Doe's Mother-in-Law Lounge," which houses a life-size statue of K-Doe himself. The club was severely damaged by Hurricane Katrina in late 2005 and had to shut down. With the help of the Hands on Network and the musical artist, Usher Raymond, Antoinette reopened the Mother-in-Law Lounge on August 28, 2006 in its original location at 1500 N. Claiborne Avenue
Antoinette died in New Orleans on February 24, 2009, the Mardi Gras day, after suffering a massive heart attack